Mendelian randomization with a binary exposure variable: interpretation and presentation of causal estimates
نویسندگان
چکیده
منابع مشابه
Mendelian Randomization with a Binary Outcome
Analogous to randomized clinical trials (RCT), Mendelian randomization (MR) divides subjects into two or more groups. However, MR uses a genetic variable, such as the state of a certain gene, to form the groups. The state of the gene is assumed to be random. Using two-stage least squares and making several assumptions, the causal impact of an exposure variable on the outcome variable can be mea...
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In epidemiological research, the causal effect of a modifiable phenotype or exposure on a disease is often of public health interest. Randomized controlled trials to investigate this effect are not always possible and inferences based on observational data can be confounded. However, if we know of a gene closely linked to the phenotype without direct effect on the disease, it can often be reaso...
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In this paper, the authors describe different instrumental variable (IV) estimators of causal risk ratios and odds ratios with particular attention to methods that can handle continuously measured exposures. The authors present this discussion in the context of a Mendelian randomization analysis of the effect of body mass index (BMI; weight (kg)/height (m)(2)) on the risk of asthma at age 7 yea...
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Background: Adiposity, as indicated by body mass index (BMI), has been associated with risk of cardiovascular diseases in epidemiological studies. We aimed to investigate if these associations are causal, using Mendelian randomization (MR) methods. Methods: The associations of BMI with cardiovascular outcomes [coronary heart disease (CHD), heart failure and ischaemic stroke], and associations o...
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Instrumental variable analysis is an approach for obtaining causal inferences on the effect of an exposure (risk factor) on an outcome from observational data. It has gained in popularity over the past decade with the use of genetic variants as instrumental variables, known as Mendelian randomization. An instrumental variable is associated with the exposure, but not associated with any confound...
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ژورنال
عنوان ژورنال: European Journal of Epidemiology
سال: 2018
ISSN: 0393-2990,1573-7284
DOI: 10.1007/s10654-018-0424-6